[1]仲雷,张建国,郭宝良,等.乳腺小黏蛋白在检测乳腺癌患者外周血微转移中的意义[J].中华乳腺病杂志(电子版),2008,2(1):40-47.
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乳腺小黏蛋白在检测乳腺癌患者外周血微转移中的意义()

中华乳腺病杂志（电子版）[ISSN:1674-0807/CN:11-9146/R]

卷:
第2卷
期数:
2008年1期
页码:
40-47
栏目:
临床研究
出版日期:
2008-02-01

文章信息/Info

作者:
仲雷;张建国;郭宝良;杨学伟;单明
哈尔滨医科大学附属二院乳腺外科
关键词:
乳腺癌; 微转移; 巢式逆转录聚合酶链反应; SBEM-mRNA
摘要:
目的：探讨乳腺小黏蛋白(small breast epithelial mucin，SBEM)mRNA作为检测乳腺癌患者外周血微转移指标的临床意义。 方法：用巢式逆转录聚合酶链反应（Nested RT PCR）法检测22例女性胃癌、16例结/直肠癌、107例乳腺癌、40例乳腺纤维腺瘤患者和27例健康志愿者外周血中SBEM-mRNA的表达情况。 结果：107例乳腺癌患者外周血中SBEM-mRNA有57例表达，阳性率为53.27%，其余对照组中SBEM-mRNA表达均为阴性。两组比较差异有统计学意义(P＜0.05）。SBEM-mRNA的阳性表达与患者的淋巴结转移状况和TNM分期均有相关性(P均＜0.01）；而与患者的年龄、原发肿瘤大小、病理类型、ER、PR等无相关性(P＞0.05)。 结论：SBEM-mRNA特异表达于乳腺癌患者的外周血，可能成为检测乳腺癌患者外周血中微转移和判断预后的指标之一。

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更新日期/Last Update: 2008-01-20