[1]王欣,闫哲,李晓青,等.Cystatin M在乳腺癌及转移癌中的表达和临床意义[J].中华乳腺病杂志(电子版),2008,2(3):294.
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Cystatin M在乳腺癌及转移癌中的表达和临床意义()

中华乳腺病杂志（电子版）[ISSN:1674-0807/CN:11-9146/R]

卷:
第2卷
期数:
2008年3期
页码:
294
栏目:
实验研究
出版日期:
2008-06-01

文章信息/Info

作者:
王欣;闫哲;李晓青;冯玉梅;曹旭晨
天津医科大学肿瘤医院人才启动基金（编号6-28）资助
天津医科大学附属肿瘤医院乳腺一科(王欣、闫哲、曹旭晨)；生化及分子生物研究室(李晓青、冯玉梅)；乳腺癌防治教育部重点实验室(王欣、闫哲、李晓青、冯玉梅、曹旭晨)
关键词:
乳腺癌; Cystatin M; mRNA表达; 转移
摘要:
目的 探讨cystatin M在乳腺癌及转移癌中的表达和临床意义。方法 采用RT-PCR检测108例乳腺癌标本、30例转移癌标本及24例癌旁正常乳腺组织中cystatin M mRNA表达水平，分析cystatin M基因表达与临床病理参数的关系。结果 乳腺癌标本中cystatin M在Ⅰ、Ⅱ期乳腺癌患者中表达较高，而在III/IV期乳腺癌患者中表达较低，两者间差异有统计学意义；cystatin M在5 cm以下肿瘤中表达较高，而在5 cm以上肿瘤中表达较低，两者间差异有统计学意义；乳腺癌标本中cystatin M表达量与正常乳腺组织的差异无统计学意义；乳腺癌标本中cystatin M表达量与转移癌标本的差异也无统计学意义；乳腺癌标本中cystatin M mRNA表达水平与乳腺癌患者是否发生淋巴结转移、淋巴结转移数、组织学分级、病理学类型无关；乳腺癌标本和转移癌标本中cystatin M mRNA表达水平与人表皮生长因子受体2状态，雌激素受体状态及孕激素受体状态无关。结论 Cystatin M是否为监测乳腺癌浸润转移的可靠指标仍需探讨。

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更新日期/Last Update: 2008-01-20