[1]郝晓甍,张瑾.血管内皮生长因子-C及其受体Flt4表达与乳腺癌临床病理状态及预后相关性研究[J].中华乳腺病杂志(电子版),2008,2(4):443-451.
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血管内皮生长因子-C及其受体Flt4表达与乳腺癌临床病理状态及预后相关性研究()

中华乳腺病杂志（电子版）[ISSN:1674-0807/CN:11-9146/R]

卷:
第2卷
期数:
2008年4期
页码:
443-451
栏目:
实验研究
出版日期:
2008-08-01

文章信息/Info

作者:
郝晓甍;张瑾
天津医科大学附属肿瘤医院乳腺科
关键词:
乳腺癌; 血管内皮生长因子-C; Flt4; 淋巴结转移
摘要:
目的　研究血管内皮生长因子-C（VEGF-C）及其受体Flt4在乳腺癌中的表达及其表达程度与肿瘤临床病理特征及预后的关系。方法　收集手术切除后行石蜡包埋的乳腺癌标本60例，制作成4μm厚的连续切片，经免疫组织化学染色后观察乳腺癌组织中VEGF-C、Flt4的表达情况。结果　（1）乳腺癌细胞VEGF-C与其受体Flt4表达呈正相关（P<0.01）；（2）VEGF-C与PCNA表达显著相关（P<0.01）；（3）Flt4与增殖细胞核抗原（PCNA）表达显著相关（P<0.01）；（4）淋巴结转移组乳腺癌细胞VEGF-C/Flt4阳性指数明显高于未转移组（P<0.05）；（5）VEGF-C与患者年龄、肿瘤大小、组织学分级、ER、PR及病理类型无统计学关系（均P>0.05）；（6）VEGF-C与预后无统计学关系。结论　VEGF-C/Flt4调控系统在乳腺癌细胞增殖中起一定的促进作用；VEGF-C/Flt4可能通过某种机制促进淋巴结转移；VEGF-C不能作为判断乳腺癌预后的独立指标。

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更新日期/Last Update: 2008-01-20