[1]刘鹏熙,周瑞芳,许锐,等.唑来膦酸与帕米膦酸二钠治疗乳腺癌骨转移性疼痛的近期疗效观察[J].中华乳腺病杂志(电子版),2008,2(4):402-406.
点击复制

唑来膦酸与帕米膦酸二钠治疗乳腺癌骨转移性疼痛的近期疗效观察()

中华乳腺病杂志（电子版）[ISSN:1674-0807/CN:11-9146/R]

卷:
第2卷
期数:
2008年4期
页码:
402-406
栏目:
临床研究
出版日期:
2008-08-01

文章信息/Info

作者:
刘鹏熙;周瑞芳;许锐;陈前军;钟少文;林毅
广州中医药大学第二附属医院乳腺科
关键词:
乳腺癌; 骨转移; 唑来膦酸; 帕米膦酸二钠
摘要:
目的　评价唑来膦酸与帕米膦酸二钠治疗乳腺癌骨转移性疼痛的近期疗效及不良反应。方法　所有病例均为乳腺癌骨转移患者，其中唑来膦酸组２９例，帕米膦酸二钠组２５例。给药方法：唑来膦酸４ｍｇ＋生理盐水５０ｍｌ静脉滴注１５ｍｉｎ；帕米膦酸二钠６０ｍｇ＋生理盐水５００ｍｌ静脉滴注４ｈ；均每４周１次，共３次。记录治疗效果及不良反应。结果　疼痛缓解情况：唑来膦酸组完全缓解（ＣＲ）１５例（５１．７％），部分缓解（ＰＲ）９例（３１．０％），临床获益［ＣＲ＋ＰＲ＋轻度缓解（ＭＲ）］９３．０％；帕米膦酸二
钠组ＣＲ１１例（４４．０％），ＰＲ７例（２８．０％），临床获益８８．０％。主要不良反应为发热、感冒样症状、低钙血症。结论　唑来膦酸与帕米膦酸二钠对乳腺癌转移性骨痛有较好的疗效；两药的治疗效果及不良反应相似，但唑来膦酸使用更为方便。

相似文献/References:

[1]蒋宏传.乳腺癌根治术后乳房再造方法的选择[J].中华乳腺病杂志(电子版),2007,1(1):1.
　JIANG Hong-chuan.Selection of breast reconstlh_paperctive method after radical resection in breast cancer[J].Chinese Journal of Breast Disease (Electronic Version),2007,1(4):1.
[2]王永胜.乳腺癌前哨淋巴结活检研究进展[J].中华乳腺病杂志(电子版),2007,1(1):7.
　YANG Ming-tian,LIAN Zheng-qiang.Advancement of endocrine therapy in breast cancer[J].Chinese Journal of Breast Disease (Electronic Version),2007,1(4):7.
[3]杨名添,连臻强.乳腺癌内分泌治疗的进展[J].中华乳腺病杂志(电子版),2007,1(1):14.
　WANG Yong-sheng.Advancement of sentinel lymph node in breast cancer[J].Chinese Journal of Breast Disease (Electronic Version),2007,1(4):14.
[4]刘鹏熙,钟少文,陈前军.乳腺癌保乳术后背阔肌微肌瓣转移乳房整形[J].中华乳腺病杂志(电子版),2007,1(1):25.
　LIAN Peng-xi,ZHONG Shao-wen,CHEN Qian-jun.The use of a lastissimus doris miniflap for immediate correction of the deformity resulting from breast conservation surgery[J].Chinese Journal of Breast Disease (Electronic Version),2007,1(4):25.
[5]王毅本,盛桦,曾小兵.乳腺癌术后引流液细胞学检查得临床价值[J].中华乳腺病杂志(电子版),2007,1(1):29.
　WANG Yi-ben,SHENG Hua,ZENG Xiao-bing.Examination of exfoliative cytology of draining liquid in patients with breast tumor[J].Chinese Journal of Breast Disease (Electronic Version),2007,1(4):29.
[6]王水,刘晓安,赵佳.联合法观察前哨淋巴通道的临床研究[J].中华乳腺病杂志(电子版),2007,1(1):55.
　WANG Shui,LIU Xiao-an,ZHAO Jia.The study on sentinel lymphatic channels by using methylene blue and technetium 99m sulfur colloid in breast cancer patients[J].Chinese Journal of Breast Disease (Electronic Version),2007,1(4):55.
[7]曾晓华,刘长安,邓建川.RNAi 抑制hTERT基因治疗乳腺癌的实验研究[J].中华乳腺病杂志(电子版),2007,1(1):61.
　ZENG Xiao-hua,LIU Chang-an,DENG Jian-chuan.Experimental research of targeting hTERT gene inhibited in breast cancer therapy by RNA interference[J].Chinese Journal of Breast Disease (Electronic Version),2007,1(4):61.
[8]陈治,耿翠芝.植物雌激素与乳腺癌关系得研究进展[J].中华乳腺病杂志(电子版),2007,1(1):67.
　CHEN Zhi,GEGN Cui-zhi.Advancement of the relationship between phytoestrogen and breast cancer[J].Chinese Journal of Breast Disease (Electronic Version),2007,1(4):67.
[9]唐鹏,姜军.类固醇受体辅活化因子家族与乳腺癌[J].中华乳腺病杂志(电子版),2007,1(1):74.
　TANG Peng,JIANG Jun.steroid receptor coactivator family and breast cancer[J].Chinese Journal of Breast Disease (Electronic Version),2007,1(4):74.
[10]张炳先,吴秀萍,蔡明勇.Ⅰ、Ⅱ期乳腺癌１３２例的治疗体会[J].中华乳腺病杂志(电子版),2007,1(1):90.
　ZHANG Bing-xian,WU Xiu-ping,CAI Ming-yong.Expeience of treatmen in 132 canses of stage ⅠandⅡ breast cancer[J].Chinese Journal of Breast Disease (Electronic Version),2007,1(4):90.
[11]徐海滨,胡组健,胡望华.乳腺癌骨转移综合治疗初探[J].中华乳腺病杂志(电子版),2007,1(1):87.
　XU Hai-bin,HU Zu-jian,HU Wang-hua.Preliminary exploration of combined therapy in bone metastasis of breast cancer[J].Chinese Journal of Breast Disease (Electronic Version),2007,1(4):87.

更新日期/Last Update: 2008-01-20