[1]赵菲,姜军.乳腺癌中骨桥蛋白表达的研究进展[J].中华乳腺病杂志(电子版),2008,2(5):571-579.
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乳腺癌中骨桥蛋白表达的研究进展()

中华乳腺病杂志(电子版)[ISSN:1674-0807/CN:11-9146/R]

卷:
第2卷
期数:
2008年5期
页码:
571-579
栏目:
综述
出版日期:
2008-10-01

文章信息/Info

作者:
赵菲;姜军
第三军医大学附属西南医院乳腺疾病中心
关键词:
骨桥蛋白乳腺癌
摘要:
骨桥蛋白(osteopontin,OPN)是细胞外基质中重要的功能性蛋白,因其最早发现于牛骨组织的成骨细胞与破骨细胞之内,介导骨组织细胞与骨基质的连接,参与骨基质矿化和重吸收过程而得名[1]。随着研究的深入,在许多非矿化组织如肾、内耳、蜕膜、胎盘、平滑肌及活化T细胞、巨噬细胞等之中亦发现有OPN的存在;在尿液、乳汁及已发生远处转移的肿瘤患者血液中也可检测到OPN表达。作为一种机体反应蛋白,OPN在泌尿系结石形成、机体感染与免疫、损伤修复、组织间质重塑、肿瘤浸润转移等过程中的作用日益受到重视,同样在乳腺癌发生、发展中的作用亦不容忽视。

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更新日期/Last Update: 2008-01-20