[1]马小军,蒲永东,何建苗.晚期乳腺癌术前区域性动脉灌注化疗后微血管密度及微淋巴管密度的变化[J].中华乳腺病杂志(电子版),2007,1(3):24.
　MA Xiao-jun,PU Yong-dong,HE Jian-miao.Effect of preoperative regional intra-arterial infusion chemotherapy on MVD and LMVD in advanced breast cancer[J].Chinese Journal of Breast Disease (Electronic Version),2007,1(3):24.
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晚期乳腺癌术前区域性动脉灌注化疗后微血管密度及微淋巴管密度的变化()

中华乳腺病杂志（电子版）[ISSN:1674-0807/CN:11-9146/R]

卷:
第1卷
期数:
2007年3期
页码:
24
栏目:
临床研究
出版日期:
2007-06-01

文章信息/Info

Title:
Effect of preoperative regional intra-arterial infusion chemotherapy on MVD and LMVD in advanced breast cancer
作者:
马小军;蒲永东;何建苗
解放军总医院第二附属医院普外科(马小军、蒲永东、何建苗);空军指挥学院医院外科（马小军、赵秀坤）
Author(s):
MA Xiao-jun;PU Yong-dong;HE Jian-miao
关键词:
乳腺癌; 动脉灌注化疗; 微血管密度; 淋巴管密度
摘要:
目的　探讨术前区域动脉灌注化疗及全身静脉化疗对晚期乳腺癌微血管密度（ＭＶＤ）、微淋巴管密度（ＭＬＶＤ）的影响。方法　将７６例晚期乳腺癌患者随机分为２组，术前动脉灌注化疗组３５例，术前全身静脉化疗组４１例，选其中２５例化疗前的乳腺癌患者作对照组。采用免疫组化ＳＰ法，用ＣＤ３４、ＶＥＧＦＲ３抗体对３组乳腺癌组织标本进行ＭＶＤ、ＭＬＶＤ检测。结果　术前动脉灌注化疗组的ＭＶＤ为３６．０５±１３．６４，全身静脉化疗组为４９．９２±１２．９０，对照组为６０．３８±１３．５４，各组间比较（Ｐ＜０.０１）；术前动脉灌注化疗组的ＭＬＶＤ为６．６２±３．７０，全身静脉化疗组为９．９６±４．５７，对照组为１１．３０±５．３２，动脉灌注化疗组与对照组比较显著下降（Ｐ＜０.０１），与静脉化疗组比较差异有统计学意义（Ｐ＜０.０５），静脉化疗组与对照组比较差异无统计学意义（Ｐ＞０.０５）。结论　术前区域性动脉灌注化疗比全身静脉化疗更能有效降低肿瘤组织及其周边组织内ＭＶＤ和ＭＬＶＤ，从而抑制肿瘤细胞生长，减少肿瘤转移的机会。

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更新日期/Last Update: 2007-01-20