[1]柳晓义,胡建霞,王宇,等.TNFR II基因-196M/R多态性与乳腺癌易感性的相关性[J].中华乳腺病杂志(电子版),2008,2(2):165-170.
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TNFR II基因-196M/R多态性与乳腺癌易感性的相关性()

中华乳腺病杂志(电子版)[ISSN:1674-0807/CN:11-9146/R]

卷:
第2卷
期数:
2008年2期
页码:
165-170
栏目:
实验研究
出版日期:
2008-04-01

文章信息/Info

作者:
柳晓义;胡建霞;王宇;曹明智
青岛大学医学院附属医院乳腺外科
关键词:
乳腺癌肿瘤坏死因子α肿瘤坏死因子α受体II多态现象
摘要:
目的:探讨TNF-α受体II(TNFR II)基因第6外显子-196M/R多态性与中国北方女性乳腺癌发病的相关性。 方法:采用聚合酶链反应限制性片段长度多态性(PCR-RFLP)方法检测TNFR II基因-196M/R多态性,分析212例乳腺癌患者(实验组),218例乳腺良性病变患者(良性组)和220例健康对照者(对照组)的TNF-α受体II(TNFR II)基因多态性与乳腺癌易感性的关系。 结果: (1)650例研究对象中存在TNFR II基因-196M/R多态性。 (2)-196M/R位点的TG+GG基因型及G等位基因频率在良性病变组与对照组间差异无统计学意义,而在乳腺癌组则显著高于良性病变组和对照组(均P﹤0.05)。 结论:TNFR II基因-196M/R在乳腺癌组和对照组存在多态性,第6外显子-196M/R位点T/G多态性可能为乳腺癌发病的易感基因位点,G等位基因可能为中国北方女性乳腺癌发病的易感基因。

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更新日期/Last Update: 2008-01-20