[1]崔明,付朝江,杨彦,等.PokemonmRNA 与c-myc蛋白在乳腺癌组织中的表达及其相关性[J].中华乳腺病杂志(电子版),2010,4(6):734-740.
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PokemonmRNA 与c-myc蛋白在乳腺癌组织中的表达及其相关性()

中华乳腺病杂志（电子版）[ISSN:1674-0807/CN:11-9146/R]

卷:
第4卷
期数:
2010年6期
页码:
734-740
栏目:
实验研究
出版日期:
2010-12-01

文章信息/Info

作者:
崔明;付朝江;杨彦;冯雁康;刘嘉
成都军区昆明总医院普通外科
关键词:
乳腺癌; PokemonmRNA; c-myc蛋白; 原位杂交; 免疫组织化学
摘要:
目的 探讨人乳腺癌中原癌基因c-myc和PokemonmRNA在乳腺癌组织中的表达及其与乳腺癌发生、转移的关系。方法 收集本院2008年1月至10月45例浸润性导管癌组织标本、20例癌旁乳腺组织标本和20例正常乳腺组织标本,均为女性,年龄23～69岁。所有标本均经临床病理确诊。采用原位杂交法检测PokemonmRNA表达,采用免疫组织化学法检测c-myc表达。采用卡方检验和等级相关法进行统计分析。结果(1)PokemonmRNA 的阳性表达率在乳腺癌组织、癌旁乳腺组织和正常乳腺组织中分别是71.11% (32/45),30.00% (6/20)和20.00% (4/20),3者间差异有统计学意义(P=0.000)。c-myc阳性表达率在乳腺癌组织、癌旁乳腺组织和正常乳腺组织中分别是86.67% (39/45),60.00% (12/20)和50.00% (10/20),3者间差异有统计学意义(P=0.004)。(2)乳腺癌细胞质PokemonmRNA 表达和乳腺癌细胞质c-myc表达都与乳腺癌腋窝淋巴结转移有关(P=0.012,P=0.027)。(3)乳腺癌细胞质PokemonmRNA 表达与c-myc表达有关联性(r=0.585,P<0.000)。结论 PokemonmRNA 和c-myc蛋白可能参与乳腺导管癌的发生和转移。PokemonmRNA表达和c-myc表达两者间有相关性。

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更新日期/Last Update: 2010-01-20